Sam’s Reaction to Dean’s Scream (Episode 4.06 “Yellow Fever”). I know, this episode is basically a showcase for Dean. But I love Sam’s reaction to all of the crazy stuff Dean does in this episode. Case in point is his reaction to Dean’s girly scream after being scared by a cat. We know from the gag reel that Padalecki cracked up in reaction to Ackles’ shrieking (who wouldn’t?), but Sam’s reaction in the actual episode is priceless.